研究業績
菅原邦生 SUGAHARA KUNIO
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吉澤史昭 YOSHIZAWA FUMIAKI
- タンパク質代謝に関する論文
Effect of quality and quantity of dietary protein on 4E-BP1 and S6K1 phosphorylation of brains in aged rats.
J. Nutr. Sci. Vitaminol. 56, 319-325, 2010
2. Yoshizawa, F., Mochizuki, S., Doi, M., Yamaoka, I., and Sugahara, K.
Ethionine-induced ATP depletion represses mTOR signaling in the absence of increases in AMP-activated protein kinase activity in rat liver.
Biosci. Biotechnol. Biochem. 73, 1984-1988, 2009
3. Yamaoka, I., Doi, M., Kawano, Y., Nakayama, M., Watanabe, Y., Oba, K., Sugahara, K., and Yoshizawa, F.
Insulin mediates the linkage acceleration of muscle protein synthesis, thermogenesis, and heat storage by amino acids.
Biochem. Biophys. Res. Commun. 386, 252-256, 2009
4. Fujita, S., Dreyer, H.C., Drummond, M.J., Glynn, E.L., Cadenas, J.G., Yoshizawa, F., Volpi, E., and Rasmussen, B.B.
Nutrient Signalling in the Regulation of Human Muscle Protein Synthesis.
J. Physiol. 582, 813-823, 2007
5. Yamaoka, I., Doi, M., Nakayama, M., Ozeki, A., Mochizuki, S., Sugahara, K., and Yoshizawa, F.
Intravenous administration of amino acids during anesthesia stimulates muscle protein synthesis and heat accumulation in the body.
Am. J. Physiol. Endocrinol. Metab. 290, E882-E888, 2006
6. Hashi, M., Yoshizawa, F., Onozuka, E., Ogata, M., and Hara, H.
Adaptive changes in translation initiation activities for rat pancreatic protein synthesis with feeding of a high-protein diet.
J. Nutr. Biochem. 16, 507-512, 2005
7. Nagasawa, T., Kikuchi, N., Ito, Y., Yoshizawa, F., and Nishizawa, N.
Suppression of myofibrillar protein degradation after refeeding in young and adult mice.
J. Nutr. Sci. Vitaminol. 50, 227-230, 2004
8. Yoshizawa, F., Sekizawa, H., Hirayama, S., Yamazaki, Y., Nagasawa, T., and Sugahara, K.
Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by ?-ketoisocaproate.
J. Nutr. Sci. Vitaminol. 50, 56-60, 2004
9. Kanazawa, T., Taneike, I., Akaishi, R., Yoshizawa, F., Furuya, N., Fujimura, S., and Kadowaki, M.
Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes.
J. Biol. Chem. 279, 8452-8459, 2004
10. Yoshizawa, F., Watanabe, E., Sugahara, K., and Natori, Y.
Translational initiation regulators are hypophosphorylated in rat liver during ethionine-mediated ATP depletion.
Biochem. Biophys. Res. Commun. 298, 235-239, 2002
11. Yoshizawa, F., Hirayama, S., Sekizawa, H., Nagasawa, T., and Sugahara, K.
Oral administration of leucine stimulates phosphorylation of 4E-BP1 and S6K1 in skeletal muscle but not in liver of diabetic rats.
J. Nutr. Sci. Vitaminol. 48, 59-64, 2002
12. Nagasawa, T., Kido, T., Yoshizawa, F., Ito, Y., and Nishizawa, N.
Rapid suppression of protein degradation in skeletal muscle after oral feeding of leucine in rats.
J. Nutr. Biochem. 13, 121-127, 2002
13. Yoshizawa, F., Sekizawa, H., Hirayama, S., Hatakeyama, A., Nagasawa, T., and Sugahara, K.
Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats.
J. Nutr. Sci. Vitaminol. 47, 311-315, 2001
14. Yoshizawa, F., Kido, T., and Nagasawa, T.
Rapid dephosphorylation of eIF4E by dietary protein in the skeletal muscle and liver of food-deprived rats.
Biosci. Biotechnol. Biochem. 65, 958-961, 2001
15. Anthony, T.G., Anthony, J.C., Yoshizawa, F., Kimball, S.R., and Jefferson, L.S.
Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats.
J. Nutr. 131, 1171-1176, 2001
16. Yoshizawa, F., Miura, Y., Tsurumaru, K., Kimata, Y., Yagasaki, K., and Funabiki, R.
Elongation factor 2 in the liver and skeletal muscle of mice is decreased by starvation.
Biosci. Biotechnol. Biochem. 64, 2482-2485, 2000
17. Anthony, J.C., Yoshizawa, F., Anthony, T.G., Vary, T.C., Jefferson, L.S., and Kimball, S.R.
Leucine stimulates translation initiation in skeletal muscle of post-absorptive rats via a rapamycin-sensitive pathway.
J. Nutr. 130, 2413-2419, 2000
18. Yoshizawa, F., Kido, T., and Nagasawa, T.
Stimulative effect of dietary protein on the phosphorylation of p70 S6 Kinase in the skeletal muscle and liver of food-deprived rats.
Biosci. Biotechnol. Biochem. 63, 1803-1805, 1999
19. Yoshizawa, F., Kimball, S.R., Vary, T.C., and Jefferson, L.S.
Effect of dietary protein on translation initiation in rat skeletal muscle and liver.
Am. J. Physiol. 275, E814-E820, 1998
20. Nagasawa, T., Hirano, J., Yoshizawa, F., and Nishizawa, N.
Myofibrillar protein catabolism is rapidly suppressed following protein feeding.
Biosci. Biotechnol. Biochem. 62, 1932-1937, 1998
21. Yoshizawa, F., Kimball, S.R., and Jefferson, L.S.
Modulation of translation initiation in rat skeletal muscle and liver in response to food intake.
Biochem. Biophys. Res. Commun. 240, 825-831, 1997
22. Yoshizawa, F., Nagasawa, T., Nishizawa, N., and Funabiki, R.
Protein synthesis and degradation change rapidly in response to food intake in muscle of food-deprived mice.
J. Nutr. 127, 1156-1159, 1997
23. Yamauchi, T., Tobe, K., Tamemoto, H., Ueki, K., Kaburagi, Y., Yamamoto-Honda, R., Takahashi, Y., Yoshizawa, F., Aizawa, S., Akanuma, Y., Sonenberg, N., Yazaki, Y., and Kadowaki, T.
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
Mol. Cell. Biol. 16, 3074-3084, 1996
24. Nagasawa, T., Yoshizawa, F., and Nishizawa, N.
Plasma N-Methylhistidine concentration is a sensitive index of myofibrillar protein degradation during starvation in rats.
Biosci. Biotechnol. Biochem. 60, 501-502, 1996
25. Yoshizawa, F., Endo, M., Ide, H., Yagasaki, K., and Funabiki, R.
Translational regulation of protein synthesis in the liver and skeletal muscle of mice in response to refeeding.
J. Nutr. Biochem. 6, 130-136, 1995
26. Yoshizawa, F., Tonouchi, A., Miura, Y., Yagasaki, K., and Funabiki, R.
Insulin-stimulated polypeptide chain elongation in the soleus muscle of mice.
Biosci. Biotechnol. Biochem. 59, 348-349, 1995
27. Funabiki, R., Yagasaki, K., Hara, H., Nyumura, N., Yoshizawa, F., and Saito, K.
In vivo effect of L-leucine administration on protein synthesis in mice.
J. Nutr. Biochem. 3, 401-407, 1992
- 糖代謝に関する論文
分枝鎖アミノ酸の代謝調節因子としての機能．
栄養生理研究会報, 54, 9-20, 2010
2. 吉澤史昭．
分岐鎖アミノ酸によるタンパク質代謝調節と糖代謝調節．
アミノ酸研究, 1, 9-17. 2008
3. Doi, M., Yamaoka, I., Nakayama, M., Sugahara, K., and Yoshizawa, F.
Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.
Am. J. Physiol. Endocrinol. Metab. 292, E1683-E1693, 2007
4. 吉澤史昭、渡辺陽介，土居雅子、山岡一平、中山満雄、菅原邦生
イソロイシンの経口投与による血糖値低下作用の解析
必須アミノ酸研究 NO.175, 1-7, 2006
5. Doi, M., Yamaoka, I., Nakayama, M., Mochizuki, S., Sugahara, K., and Yoshizawa, F. Isoleucine, a Blood Glucose-Lowering Amino Acid, Increases Glucose Uptake in Rat Skeletal Muscle in the Absence of Increases in AMP-Activated Protein Kinase Activity. J. Nutr. 135, 2103-2108, 2005
- その他の論文
Oral administration of lysine restores food intake and ventromedial hypothalamic dopamine in chicken on a lysine-free diet.
Br. Poult. Sci. (in press)
2. Alam MR, Yoshizawa F, and Sugahara K.
Local administration of l-DOPA in the chicken ventromedial hypothalamus increases dopamine release in a dose-dependent manner.
Neurosci Lett. 529: 150-154, 2012
3. Alam, M.R., Yoshizawa, F., and Sugahara, K.
L-DOPA induced extracellular dopamine increases in the ventromedial hypothalamus affects food intake by chickens on a lysine-free diet.
Neurosci. Lett. 495, 126-129, 2011
4. Khalil, A.M., Ichijo, A., Yoshizawa, F., and Sugahara, K.
Effect of surgery for cannula implantation into the hypothalamus on the behaviour and neural activity of broiler chicks.
Br. Poult. Sci. 51, 146-151, 2010
5. Ichijo, A., Hayashi, N., Fukuoka, C., Hu, J. J., Yoshizawa, F., and Sugahara, K.
Dopamine release in the ventromedial hypothalamus of growing chickens decreases when they are fed a lysine devoid diet.
J. Poult. Sci. 45, 281-286, 2008
6. Zhou, W., Aoyama, M., Yoshizawa, F., and Sugahara, K.
Developmental increases in hypothalamic neuropeptide Y content with the embryonic age of meat- and layer-type chicks.
Brain. Res. 1072, 26-29, 2006
7. Elkhalil, A.O., Nilsen-Hamilton, M., Yoshizawa, F., and Sugita, S.
Expression of SIP24 in the peripartum and postpartum rat uterus.
Connect. Tissue. Res. 46, 235-241, 2005
8. Zhou, W., Murakami, M., Hasegawa, S., Yoshizawa, F., and Sugahara K.
Neuropeptide Y content in the hypothalamic paraventricular nucleus responds to fasting and refeeding in broiler chickens.
Comp. Biochem. Physiol. A Mol. Integr. Physiol. 141, 146-152, 2005
9. Tachibana, T., Hiramatsu, K., Furuse, M., Hasegawa, S., Yoshizawa, F., and Sugahara K.
Distribution of proglucagon mRNA and GLP-1 in the brainstem of chicks.
Comp. Biochem. Physiol. A Mol. Integr. Physiol. 140, 203-207, 2005
10. Sugahara, K., Matsumoto, M., Yamada, M., Yoshizawa, F., and Karasawa, Y.
Effect of bilateral cecal ligation on use of dietary energy in growing chickens.
Anim. Sci. J. 75, 417-422, 2004
11. Tachibana, T., Hirofuji, K., Matsumoto, M., Furuse, M., Hasegawa, S., Yoshizawa, F., and Sugahara, K.
The hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 in chicks.
Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 137, 183-188, 2004
12. Tachibana, T,, Matsumoto, M., Furuse, M., Hasegawa, S., Yoshizawa, F., and Sugahara, K.
Central, but not peripheral, glucagon-like peptide-1 inhibits crop emptying in chicks.
Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 134, 777-781, 2003
- 総説
アミノ酸の代謝調節因子としての機能．
内分泌・糖尿病・代謝内科 34，320-327, 2012
2. Yoshizawa, F.
New therapeutic strategy for amino Acid medicine: notable functions of branched chain amino acids as biological regulators.
J Pharmacol Sci. 118, 149-155, 2012
3. 吉澤史昭．
生体調節因子として新たに注目される分岐鎖アミノ酸．
バイオサイエンスとインダストリー 67, 238-244, 2009
4. 土居雅子，山岡一平，中山満雄，菅原邦生，吉澤史昭．
アミノ酸による血糖値低下作用?イソロイシンのグルコース代謝へ及ぼす影響について?
栄養生理研究会報 52, 27-36, 2008
5. 吉澤史昭．
スポーツとアミノ酸
Functional Food 2 (3), 240-248 , 2008
6. 吉澤史昭、長澤孝志
代謝調節因子として注目される分岐鎖アミノ酸
化学と生物，45(3), 203-210, 2007
7. Yoshizawa, F., Nagasawa, T., and Sugahara, K.
Effect of orally administered branched-chain amino acids on protein synthesis and degradation in rat skeletal muscle.
Asian-Aust. J. Animal. Sci. 18, 133-140, 2005
8. 吉澤史昭
タンパク質合成の調節機構とアミノ酸
臨床スポーツ医学 22(7) 785-791, 2005
9. Yoshizawa, F.
Regulation of protein synthesis by branched-chain amino acids in vivo.
Biochem. Biophys. Res. Commun. 313, 417-422, 2004
10. 吉澤史昭
分岐鎖アミノ酸による体タンパク質の代謝制御
栄養生理研究会報. 47(2), 9-26, 2003
- 著書
2. Sato, E., Yoshizawa, F., Kai, O., Hanzawa, K., Sato, M., Kashiwazaki, N., Terada, F., Yasue, T., Ozawa, T., Koizumi, S., A brief history of the Japanese Society of Animal Science(JSAS) and recent achievements published in the official journal of the JSAS, Animal production and animal science worldwide -WAAP book of the year 2007-, pp.41-50 Wageningen Academic Publisher, ISBN 978-9086860685 (2009)
3. 吉澤史昭、佐藤 英明，第31章畜産学，日本農学80年史，pp. 養賢堂，ISBN 978-4-8425-0461-2 (2009)
4. 吉澤史昭（分担執筆），第２章 分岐鎖アミノ酸とタンパク質合成制御，アミノ酸の機能特性 （（社）日本栄養・食糧学会 監修，矢ヶ崎一三，門脇基二，舛重正一，横越英彦 責任編集），pp.49-88，建帛社，ISBN 978-4-7679-6111-8，(2007)
5. 吉澤史昭（分担執筆），第３章 タンパク質合成とアミノ酸，タンパク質・アミノ酸の科学 （岸恭一，西村敏英 監修，（社）日本必須アミノ酸協会 編），pp.117-178，工業調査会，ISBN 978-4-7693-7155-7，(2007)
6. 吉澤史昭（分担執筆），第２章 栄養素の代謝と機能 2.タンパク質の生合成，栄養・食糧学 データハンドブック（（社）日本栄養・食糧学会 編），pp.87-90，同文書院，ISBN 4-8103-0032-3，(2006)
7. 吉澤史昭（分担執筆），6.4 タンパク質合成のシグナル伝達，分子栄養学 (金本龍平 編), pp.100-105，化学同人，ISBN 4-7598-1214-8，(2005)
8. 吉澤史昭（分担執筆），VII タンパク質合成に関与する重要因子の測定法 4-6節，
タンパク質代謝研究法（野口忠，舩引龍平，門脇基二 編著），pp.155-180,
学会出版センター, ISBN 4-7622-2940-7，(2000)
9. 吉澤史昭（分担執筆），４章. 疾患モデルと遺伝子導入動物 a. 疾患モデルの作製とその利用(5)糖尿病，細胞外マトリクス研究法（５）?基礎知識からデータの解釈まで? 第IV部．機能解析法 下（畑隆一郎，服部俊治，新井克彦 編）, pp.73-80，コラーゲン技術研修会，ISBN 4-907673-05-1, (1999)
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