List of Works

1/4/2010 Update


 

 about regulation of translation

   1) Fujita, S., Dreyer, H.C., Drummond, M.J., Glynn, E.L., Cadenas, J.G., Yoshizawa, F., Volpi, E., and
         Rasmussen, B.B.     
         Nutrient Signalling in the Regulation of Human Muscle Protein Synthesis.
        
J. Physiol. (in press)
     2) Yamaoka, I., Doi, M., Nakayama, M., Ozeki, A., Mochizuki, S., Sugahara, K., and
Yoshizawa, F.
         Intravenous administration of amino acids during anesthesia stimulates muscle protein synthesis and heat accumulation in the body.
         
Am. J. Physiol. 290, E882-888, 2006
     3) Hashi, M.,
Yoshizawa, F., Onozuka, E., Ogata, M., and Hara, H.
         Adaptive changes in translation initiation activities for rat pancreatic protein synthesis with feeding of a high-protein diet.

          J. Nutr. Biochem.
16, 507-512, 2005
     4)
Yoshizawa F., Sekizawa, H., Hirayama, S., Yamazaki, Y., Nagasawa, T., and Sugahara, K.
         Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate.
     
    J. Nutr. Sci. Vitaminol. 50, 56-60, 2004
     5)
Yoshizawa F., Watanabe E., Sugahara K., and Natori Y.
         Translational initiation regulators are hypophosphorylated in rat liver during ethionine-mediated ATP depletion.
        
Biochem. Biophys. Res. Commun. 298, 235-239, 2002
     6) Yoshizawa F., Hirayama, S., Sekizawa, H., Nagasawa, T., and Sugahara, K.
         Oral administration of leucine stimulates phosphorylation of 4E-BP1 and S6K1 in skeletal muscle but not in
         liver of diabetic rats.
J.Nutr.Sci.Vitaminol. 48, 59-64, 2002
    7)
Yoshizawa F., Sekizawa, H., Hirayama, S., Hatakeyama, A., Nagasawa, T., and Sugahara, K.
         Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats. 
         J.Nutr.Sci.Vitaminol. 47, 311-315, 2001
    8)
Yoshizawa F., Kido T., and Nagasawa T.
         Rapid dephosphorylation of eIF4E by dietary protein in the skeletal muscle and liver of food-deprived rats. 
         Biosci. Biotechnol. Biochem. 65, 958-961, 2001
    9) Anthony, T.G., Anthony, J.C.,
Yoshizawa, F., Kimball, S.R., and Jefferson, L.S.
         Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein 
         synthesis in the liver of rats.
J .Nutr. 131, 1171-1176, 2001
    10)
Yoshizawa, F., Miura, Y., Tsurumaru, K., Kimata, Y., Yagasaki, K., and Funabiki, R. 
         Elongation factor 2 in the liver and skeletal muscle of mice is decreased by starvation. 
       
  Biosci.Biotechnol.Biochem. 64, 2482-2485, 2000
    11) Anthony, J.C.,
Yoshizawa, F., Anthony, T.G., Vary, T.C., Jefferson, L.S., and Kimball, S.R.
         Leucine stimulates translation initiation in skeletal muscle of post-absorptive rats via a rapamycin-sensitive 
         pathway.
J.Nutr. 130, 2413-2419, 2000 
    12)
Yoshizawa, F., Kido, T., and Nagasawa, T. 
         Stimulative effect of dietary protein on the phosphorylation of p70 S6 Kinase in the skeletal muscle and liver 
         of food-deprived rats.
Biosci.Biotechnol.Biochem. 63, 1803-1805, 1999

 


 

about protein metabolisms

     1) Kanazawa, T., Taneike, I., Akaishi, R., Yoshizawa, F., Furuya, N., Fujimura, S., and Kadowaki, M.
         Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to
@@@@mTOR in isolated rat hepatocytes.
         
J. Biol. Chem. 279, 8452-8459, 2004
@@@@@@2
) Nagasawa, T.,  Kido, T., Yoshizawa, F.,  Ito, Y., and Nishizawa, N.
         Rapid suppression of protein degradation in skeletal muscle after oral feeding of leucine in rats.
        J. Nutr. Biochem. 13, 121-127, 2002
     3) Nagasawa, T., Hirano, J., Yoshizawa, F., and Nishizawa, N.
         Myofibrillar protein catabolism is rapidly suppressed following protein feeding. 
        Biosci. Biotechnol. Biochem. 62, 1932-1937, 1998
     4) Yoshizawa, F., Nagasawa, T., Nishizawa, N., and Funabiki, R.
         Protein synthesis and degradation change rapidly in response to food intake in muscle of food-deprived mice. 
         J. Nutr. 127, 1156-1159, 1997
     5) Nagasawa, T., Yoshizawa, F., and Nishizawa, N.
         Plasma N-Methylhistidine concentration is a sensitive index of myofibrillar protein degradation
                                 during starvation in rats. Biosci. Biotechnol. Biochem. 60, 501-502, 1996

     6) Funabiki, R., Yagasaki, K., Hara, H., Nyumura, N., Yoshizawa, F., and Saito, K. 
         In vivo effect of L-leucine administration on protein synthesis in mice. 
        J. Nutr. Biochem. 3, 401-407, 1992


about sugar metabolisms

    1) Doi, M., Yamaoka, I., Nakayama, M., Sugahara, K., and Yoshizawa, F.
         Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and
@@@@@whole body glucose oxidation, and decreased hepatic gluconeogenesis.
        
Am. J. Physiol. Endocrinol. Metab. (in press)
     2) Doi, M., Yamaoka, I., Nakayama, M., Mochizuki, S., Sugahara, K., and
Yoshizawa, F.
         Isoleucine, a Blood Glucose-Lowering Amino Acid, Increases Glucose Uptake in
           Rat Skeletal Muscle in the Absence of Increases in AMP-Activated Protein Kinase Activity.
         
J. Nutr. 135, 2103-2108, 2005